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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Nuclear receptor coregulators ： ウィキペディア英語版 Nuclear receptor coregulators Nuclear receptor coregulators〔This article is based on the transcript of an animated course on the Nuclear Receptor Signaling Atlas (NURSA) website entitled "Nuclear receptor signaling: concepts and models". Permission to re-use this material was obtained from the original copyright holder, the Nuclear Receptor Signaling Atlas, on August 25th 2008.〕 are a class of transcription coregulators that have been shown to be involved in any aspect of signaling by any member of the nuclear receptor superfamily. A comprehensive database of nuclear receptor coregulators can be found at the (Nuclear Receptor Signaling Atlas website ). == Introduction == The ability of nuclear receptors to alternate between activation and repression in response to specific molecular cues, is now known to be attributable in large part to a diverse group of cellular factors, collectively termed coregulators and including coactivators and corepressors. The study of nuclear receptors owed a debt to decades of historical endocrinology and pathology, and prior to their discovery there was a wealth of empirical evidence that suggested their existence. Coregulators, in contrast, have been the subject of a rapid accumulation of functional and mechanistic data which is yet to be consolidated into an integrated picture of their biological functions. While this article refers to the historical terms "coactivator" and "corepressor" it should be noted that this distinction is less clear than was at first thought, and it is now known that cell type, cell signaling state and promoter identity can influence the direction of action of any given coregulator. Coregulators are often incorrectly referred to as cofactors, which are small, non-protein molecules required by an enzyme for full activity, e.g. NAD+. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Nuclear receptor coregulators」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.